Abstract The amazing diversity of B cells within the tumor microenvironment is the basis for the diverse ULTIMATE COLOR REPAIR TRIPLE RESCUE development of B cell-based immunotherapies.Here, we focus on elucidating the mechanisms of tumor intervention mediated by four tumor-infiltrating B lymphocytes.Naive B cells present the initial antigen, germi
In developed countries, most of the population recognizes that they are facing environmental and social threats which are mainly related to global warming.The problem associated with an ecological footprint, particularly water shortage, ecosystems, climate change, deforestation, and 2x5 Closure declining biodiversity, is considered a harmful threat
Abstract Microvesicles (MVs) are large extracellular vesicles differing in size, cargo and composition that share a common mechanism Charging base of release from the cells through the direct outward budding of the plasma membrane.They are involved in a variety of physiological and pathological conditions and represent promising biomarkers for dise
Abstract Many circular RNAs (circRNAs) are produced from back-splicing of exons of precursor mRNAs and are generally co-expressed with cognate linear RNAs.Methods for circRNA-specific knockout are lacking, largely due to sequence overlaps between forms.Here, we use base editors (BEs) for circRNA depletion.By targeting splice sites Charging base inv
Study region: Spring along the southeast coast of Yonaguni Island, located at the western end of the Ryukyu forearc.Study focus: The chemical composition of groundwater, including SF6 concentration, was investigated to clarify the mechanism of groundwater discharge around Sanninudai on the southeast coast of Yonaguni Island.New hydrological insight